Blar i NTNU Open på forfatter "Skarstad, Kirsten Jane"

Viser treff 1-4 av 4

    • Antibiotic-induced DNA damage results in a controlled loss of pH homeostasis and genome instability 

      Booth, James; Špírek, Mário; Lobie, Tekle Airgecho; Skarstad, Kirsten Jane; Krejci, Lumir; Bjørås, Magnar (Peer reviewed; Journal article, 2020)
      Extracellular pH has been assumed to play little if any role in how bacteria respond to antibiotics and antibiotic resistance development. Here, we show that the intracellular pH of Escherichia coli equilibrates to the ...

    • Antimicrobial resistance: A challenge awaiting the post-COVID-19 era 

      Lobie, Tekle Airgecho; Roba, Aklilu Abrham; Booth, James; Kristiansen, Knut Ivan; Aseffa, Abraham; Skarstad, Kirsten Jane; Bjørås, Magnar (Peer reviewed; Journal article, 2021)
      Microbe exposure to pharmaceutical and non-pharmaceutical agents plays a role in the development of antibiotic resistance. The risks and consequences associated with extensive disinfectant use during the COVID-19 pandemic ...

    • Peptides containing the PCNA interacting motif APIM bind to the beta-clamp and inhibit bacterial growth and mutagenesis 

      Nedal, Aina; Ræder, Synnøve Brandt; Dalhus, Bjørn; Helgesen, Emily; Forstrøm, Rune Johansen; Lindland, Kim; Sumabe, Balagra Kasim; Martinsen, Jacob H.; Kragelund, Birthe B.; Skarstad, Kirsten Jane; Bjørås, Magnar; Otterlei, Marit (Journal article; Peer reviewed, 2020)
      In the fight against antimicrobial resistance, the bacterial DNA sliding clamp, β-clamp, is a promising drug target for inhibition of DNA replication and translesion synthesis. The β-clamp and its eukaryotic homolog, PCNA, ...

    • Topoisomerase IV tracks behind the replication fork and the SeqA complex during DNA replication in Escherichia coli 

      Helgesen, Emily; Sætre, Frank Ove; Skarstad, Kirsten Jane (Peer reviewed; Journal article, 2021)
      Topoisomerase IV (TopoIV) is a vital bacterial enzyme which disentangles newly replicated DNA and enables segregation of daughter chromosomes. In bacteria, DNA replication and segregation are concurrent processes. This ...